代表作
基于光谱到光谱(Spec2Spec)框架的自监督深度学习网络已被开发出来,用以从sSMLM中的低信噪比光谱准确提取光谱信息。我们提出了一个重新采样和重新整合模块,用于生成Spec2Spec训练对。由于空间相邻像素的信号高度相关,而噪声则是独立的,因此从原始图像中采样的子图像可以作为训练输入和目标。这一方案克服了在sSMLM中获取真实基准图像的难题。通过验证Spec2Spec在模拟和实验数据上的定性和定量性能,我们证明了Spec2Spec能够实现6倍的信噪比提升和3倍的结构相似性指数(SSIM)增强,进一步促进了94.6%的光谱分类准确率和近100%的数据利用率,这些都在双色sSMLM成像中得到了应用。
一种多模态分割与融合的集成,名为SegCoFusion,它由一个名为FDNet的新型特征频率划分网络和一个使用双单路径特征补充策略的分割部分组成,以优化分割输入并与融合部分进行缝合。定性和定量结果表明,SegCoFusion能够突破分割和融合方法的现有极限。
一种一次性超声感应慢性颅窗(usCCW),具有集成的透明纳米光子超声探测器,该探测器采用软纳米压印光刻工艺制造。我们优化了传感器设计和相关的制造过程,显著提高了检测灵敏度和可靠性,这对于预期的纵向体内研究至关重要。使用这种usCCW,我们展示了在活体小鼠上连续28天对皮层血管网络进行光声显微成像。
一篇全面的综述介绍了最近在超声波检测的光学方法方面的技术进步,通过将它们根据在光声成像中的应用进行分类。对所有光学超声波检测方法进行了总体比较,进一步引入了一个理论框架,以概括光学超声波检测几何形态的灵敏度、带宽和空间响应。
这是首次利用未修饰DNA的固有对比度实现细胞结构亚衍射分辨率成像的展示。这项技术实现了亚20纳米的分辨率,为可视化单个或多个核小体的空间组织以及定量估计未染色染色体和细胞核中的核小体占有水平提供了理想方式。它提供了一个独特的可能性,使用亚衍射分析的染色体组织研究DNA的表观遗传状态。
一种被称为光谱光子定位显微术的宽场光谱光学超分辨率成像技术,能够同时捕获单个分子发射的光子的空间分布及其固有的光谱特征,具有亚纳米级的光谱分辨率。
一种新型的“超分子”设计,支持光频下的共定位磁共振和GHz频率下的振动共振,具有深亚衍射极限的空间限制(~lambda2/100)。这两种不同共振的相干耦合表现出强大的光学力,使得超分子能够根据入射光动态改变其光学属性。
开发了一种基于聚合物微环谐振器的盖玻片型透明光学超声波传感器,以满足超声波感测的高需求。微环谐振器提供极高的灵敏度、超宽带宽和更广的角度灵敏性,为高分辨率光声显微术提供了理想的解决方案。其独特的设计进一步便于将光声显微技术与现有的显微技术集成,实现同时的多功能成像。
完整列表
- D. Xu, Y. Gu, J. Lu, L. Xu, W. Wang, and B. Dong, Deep-Learning-Assisted Spectroscopic Single-Molecule Localization Microscopy Based on Spectrum-to-Spectrum Denoising. Nanoscale 16, 5729-5736 (2024)
- Y. Gu, Y. Guan, Z. Yu, and B. Dong, SegCoFusion: An Integrative Multimodal Volumetric Segmentation Cooperating With Fusion Pipeline to Enhance Lesion Awareness. IEEE Journal of Biomedical and Health Informatics 27, 5860-5871 (2023)
- B. Dong, J. Yao, and X. L. Deán-Ben, Editorial: Advances in Photoacoustic Neuroimaging. Front. Neurosci. 16, 859515 (2022)
- H. Wu, H. Chen, X. Wang, L. Yu, Z. Yu, Z. Shi, J. Xu, B. Dong, and S. Zhu, Development and Validation of an Artificial Intelligence-Based Image Classification Method for Pathological Diagnosis in Patients With Extramammary Paget’s Disease. Front. Oncol. 11, 810909 (2022)
- B. Dong, K. Song, J. L. Davis, H. F. Zhang, and C. Sun, Sub-10 nm Distance Measurements between Fluorophores using Photon-Accumulation Enhanced Reconstruction. Advanced Photonics Research 1, 2000038 (2020)
- A. Vahabakashi, A. Gelman, B. Dong, L. Gong, E. D.K. Cha, M. Schimmel, E. R. Tamm, K. Perkumas, W. D. Stamer, C. Sun, H. F. Zhang, H. Gong, and M. Johnson. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc. Natl. Acad. Sci. USA 116, 26555-26563 (2019).
- H. Li*, B. Dong*, X. Zhang*, X. Shu, X. Chen, R. Hai, D. Czaplewski, H. F. Zhang, and C. Sun, Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography. Nature Communications 10, 4277 (2019).
- T. Smart, H. Li, B. Dong, R. Hai, C. Sun, H. F. Zhang, and R. Jeanloz, High-pressure seismology: use of micro-ring resonators for characterizing acoustic emissions. Applied Physics Letters 115, 081904 (2019).
- Y. Zhang, K. Song, B. Dong, J. L. Davis, G. Shao, C. Sun, and H. F. Zhang, Multicolor super-resolution imaging using spectroscopic single-molecule localization microscopy with optimal spectral dispersion. Applied Optics 58, 2248-2255 (2019).
- E. Y. Kim, D. Y. Barefield, A. H. Vo, A. M. Gacita, E. J. Schuster, E. J. Wyatt, J. L. Davis, B. Dong, C. Sun, P. Page, L. Dellefave-Castillo, A. Demonbreun, H. F. Zhang, and E. M. McNally. Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes. JCI Insight 4, e122686 (2019).
- K. Song*, B. Dong*, C. Sun, and H. F. Zhang, Theoretical analysis of spectral precision in spectroscopic single-molecule localization microscopy. Rev. Sci. Instrum. 89, 123703 (2018).
- B. E. Urban, B. Dong, X. Zhang, H. Yang, and H. F. Zhang, Patterned-illumination second harmonic generation microscopy of collagen fibrils in rat scleras. Optics Letters 43, 5190-5193 (2018).
- X. Chen, B. Dong, C. Wang, F. Zhou, and C. Sun, Hyperbolic dispersion via symmetric and antisymmetric orderings of artificial magnetic dipole array. ACS Photonics 5, 4469-4475 (2018).
- B. Dong, J. L. Davis, C. Sun, and H. F. Zhang, Spectroscopic analysis beyond the diffraction limit. The International Journal of Biochemistry & Cell Biology 101, 113-117 (2018).
- A. Eshein, Y. Li, B. Dong, L. M. Almassalha, J. E. Chandler, T. Nguyen, K. A. Hujsak, V. P. Dravid, C. Sun, H. F. Zhang, and V. Backman, Sub-10 nm imaging of nucleic acids using spectroscopic intrinsic-contrast photon-localization optical nanoscopy (SICLON). Optics Letters 43, 5817-5820 (2018).
- J. L. Davis, B. Dong, C. Sun, and H. F. Zhang, Method to identify and minimize artifacts induced by fluorescent impurities in single-molecule localization microscopy. Journal of Biomedical Optics 23, 106501 (2018).
- X. Chen, W. Liu, B. Dong, J. Lee, H. O. T. Ware, H. F. Zhang, and C. Sun, High-speed 3D printing millimeter-size customized aspheric imaging lenses with sub 7 nm surface roughness. Advanced Materials 30, 1705683 (2018). Selected for the front cover
- B. E. Urban, L. Xiao, S. Chen, H. Yang, B. Dong, Y. Kozorovitskiy, and H. F. Zhang, In vivo super-resolution imaging of neuronal structure in the mouse brain. IEEE Transactions on Biomedical Engineering 65, 232 (2018). Selected for the front cover
- B. Dong, B. T. Soetikno, X. Chen, V. Backman, C. Sun, and H. F. Zhang, Parallel three-dimensional tracking of quantum rods using polarization-sensitive spectroscopic photon localization microscopy. ACS Photonics 4, 1747 (2017).
- B. E. Urban, L. Xiao, B. Dong, S. Chen, Y. Kozorovitskiy, and H. F. Zhang, Imaging neuronal structure dynamics using two-photon super-resolution patterned excitation reconstruction (SuPER) microscopy. Journal of Biophotonics e201700171 (2017).
- D. Yu, O. F. Khan, M. L. Suvac, B. Dong, W. K. Panek, T. Xiao, M. Wu, Y. Han, A. U. Ahmed, I. V. Balyasnikova, H. F. Zhang, S. Cheng, R. Langer, D. G. Anderson, and M. S. Lesniak, Multiplexed RNAi therapy against glioblastoma stem cells via sustained lipopolymeric nanoparticle delivery delays tumor progression. Proc. Natl. Acad. Sci. USA 114, E6147 (2017).
- S. Yu, C. Wang, Y. Zhang, B. Dong, Z. Jiang, X. Chen, W. Chen, and C. Sun, Design of nondeterministic quasi-random nanophotonic structures using fourier space representations. Scientific Reports 7, 3752 (2017).
- X. Shu, H. Li, B. Dong, C. Sun, and H. F. Zhang, Quantifying melanin concentration in retinal pigment epithelium using broadband photoacoustic microscopy. Biomedical Optics Express 8, 2851 (2017).
- B. Dong, L. Almassalha, B. T. Soetikno, J. E. Chandler, T. Nguyen, B. E. Urban, C. Sun, H. F. Zhang, and V. Backman, Stochastic fluorescence switching of nucleic acids under visible light illumination. Optics Express 25, 7929 (2017)
- B. Dong, C. Sun, and H. F. Zhang, Optical detection of ultrasound in photoacoustic imaging. IEEE Transactions on Biomedical Engineering 64, 4 (2017). Selected as the front cover
- B. Dong*, X. Chen*, F. Zhou, C. Wang, H. F. Zhang, and C. Sun, Gigahertz all-optical modulation using reconfigurable nanophotonic metamolecules. Nano Letters 16, 7690 (2016).
- B. Dong*, L. Almassalha*, Y. Stypula-Cyrus, B. E. Urban, J. E. Chandler, T. Nguyen, C. Sun, H. F. Zhang, and V. Backman, Super-resolution intrinsic fluorescence imaging utilizing native, unmodified nucleic acids for contrast. Proc. Natl. Acad. Sci. USA 113, 9716 (2016). Awarded Cozzarelli Prize, given annually to six papers published in PNAS, acknowledges papers that reflect scientific excellence and originality
- B. Dong*, L. Almassalha*, B. E. Urban*, T. Nguyen*, S. Khuon, T.-L. Chew, V. Backman, C. Sun, and H. F. Zhang, Super-resolution spectroscopic microscopy via photon localization. Nature Communications 7, 12290 (2016).
- F. Zhou*, W. Cao*, B. Dong*, T. Reissman, W. Zhang, and C. Sun, Additive Manufacturing of a 3D Terahertz Gradient-Refractive Index Lens. Advanced Optical Materials 4, 1034 (2016). Top-5 most downloaded papers, July 2016
- B. Dong, Siyu Chen, Fan Zhou, Christina H. Y. Chan, Ji Yi, Hao F. Zhang and Cheng Sun, Real-time functional analysis of inertial microfluidic devices via spectral domain optical coherence tomography. Scientific Reports 6, 33250 (2016). Highlighted by OCT News as Feature Of The Week
- X. Chen, P. Guo, C. He, B. Dong, R. D. Schaller, R. P. H. Chang and C. Sun, Scaling the Artificial Polariton Bandgap at Infrared Frequencies Using Indium Tin Oxide Nanorod Arrays. Advanced Optical Materials 4, 2077 (2016).
- A. Childs, H. Li, D. Lewittes, B. Dong, W. Liu, X. Shu, C. Sun, and H. F. Zhang, Fabricating customized hydrogel contact lens. Scientific Reports 6, 34905 (2016).
- B. E. Urban*, B. Dong*, T. Nguyen, V. Backman, C. Sun, and H. F. Zhang, Subsurface super-resolution imaging of unstained polymer nanostructures. Scientific Reports 6, 28156 (2016).
- H. Li, W. Liu, B. Dong, J. V. Kaluzny, A. A. Fawzi, and H. F. Zhang, Snapshot hyperspectral retinal imaging using compact spectral resolving detector array. Journal of Biophotonics 10, 830-839 (2016).
- X. Shu, M. Bondu, B. Dong, A. Podoleanu, L. Leick, and H. F. Zhang, A single all fiber-based nanosecond-pulsed supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography. Optics Letters 41, 2743-2746 (2016).
- S. Yu, Y. Zhang, C. Wang, W. Lee, B. Dong, C. Sun, T. Odom, and W. Chen, Characterization and design of functional quasi-random nanostructured materials using spectral density function. Proceedings of the ASME 2016 International Design Engineering Technical Conferences & Design Automation Conference (2016). Best Paper Award
- F. Zhou, C. Wang, B. Dong, X. Chen, Z. Zhang, and C. Sun, Scalable nanofabrication of U-shaped nanowire resonators with tunable optical magnetism. Optics Express 24, 6367-6380 (2016).
- S. S. Nathamgari, B. Dong, F. Zhou, W. Kang, J. P. Giraldo-Vela, T. McGuire, R. L. McNaughton, C. Sun, J. A. Kessler, and H. D. Espinosa, Isolating single cells in a neurosphere assay using inertial microfluidics. Lab on a Chip 15, 4591 (2015).
- B. Dong, H. Li, Z. Zhang, K. Zhang, S. Chen, C. Sun, and H. F. Zhang, Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection. Optica 2, 169-176 (2015).
- B. E. Urban*, J. Yi*, S. Chen*, B. Dong, Y. Zhu, S. H. DeVries, V. Backman, and H. F. Zhang, Super-resolution two-photon microscopy via scanning patterned illumination. Physical Review E 91, 042703 (2015).
- Y. Zhang, B. Dong, A. Chen, X. Liu, L. Shi, and J. Zi, Using cuttlefish ink as an additive to produce non-iridescent structural colors of high color visibility. Advanced Materials 27, 4719-4724 (2015). Selected as the inside front cover
- S. Chen, J. Yi, B. Dong, C. Sun, P. Kiser, T. J. Hope, and H. F. Zhang, Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography. Quantitative Imaging in Medicine and Surgery 5, 40-45 (2015).
- Z. Zhang, B. Dong, H. Li, F. Zhou, H. F. Zhang, and C. Sun, Theoretical and experimental studies of distance dependent response of micro-ring resonator-based ultrasonic detectors for photoacoustic microscopy. J. Appl. Phys. 116, 144501 (2014). Selected as the front cover
- B. Dong, S. Chen, Z. Zhang, C. Sun, and H. F. Zhang, Photoacoustic probe using a microring resonator ultrasonic sensor for endoscopic applications. Optics Letters 39, 4372 (2014).
- H. Li*, B. Dong*, Z. Zhang, C. Sun, and H. F. Zhang, A transparent broadband ultrasonic detector based on micro-ring resonator for functional photoacoustic imaging. Scientific Reports 4, 4496 (2014).
- Z. Zhang*, P. Ahn*, B. Dong*, O. Balogun, and C. Sun, Quantitative imaging of rapidly decaying evanescent fields using plasmonic near-field scanning optical microscopy. Scientific Reports 3, 2803 (2013).
- L. Shi, Y. Zhang, B. Dong, T. Zhan, X. Liu, and J. Zi, Amorphous photonic crystals with only short-range order. Advanced Materials 25, 5314 (2013).
- Y. Zhang, B. Dong, X. Liu, and J. Zi, Replication of spinodally decomposed structures with structural coloration from scales of the longhorn beetle Sphingnotus mirabilis. Bioinspiration & Biomimetics 8, 045003 (2013).
- H. Yin*, B. Dong*, X. Liu, T. Zhan, L. Shi, J. Zi, and Eli Yablonovitch, Amorphous diamond-structured photonic crystal in the feather barbs of the Scarlet Macaw. Proc. Natl. Acad. Sci. USA 109, 10799 (2012).
- L. Jiang, B. Dong, X. Liu, F. Liu, and J. Zi, Structural origin of sexual dichromatic lustre and iridescence in beetle Goliathus cacicus. Chin. Sci. Bull. 57, 3211 (2012).
- B. Dong, T. Zhan, X. Liu, L. Jiang, F. Liu, X. Hu, and J. Zi, Optical response of a disordered bicontinuous macroporous structure in longhorn beetle Sphingnotus mirabilis. Physical Review E 84, 011915 (2011).
- F. Liu, B. Dong, F. Zhao, X. Hu, X. Liu, and J. Zi, Ultranegative angular dispersion of diffraction in quasiordered biophotonic structures. Optics Express 19, 7750 (2011).
- J. Huang, B. Dong, and L. Zhou, Nonuniform ensembles of diverse resonances in one-dimensional layered media. Optics Letters 36, 2477 (2011).
- C. Ouyang, Z. Xiong, F. Zhao, B. Dong, X. Hu, X. Liu, and J. Zi, Slow light with low group-velocity dispersion at the edge of photonic graphene. Physical Review A 84, 015801 (2011).
- Z. Xu, B. Dong, B. Lu, Y. Chen, E. Huq, X. Qu, and R. Liu, A novel surface plasmon biosensor with imprinted waveguide metal gratings for protein detection. Microelectron. Eng. 88, 2647 (2011).
- F. Liu, Y. Liu, L. Huang, X. Hu, B. Dong, W. Shi, Y. Xie, and X. Ye, Replication of homologous optical and hydrophobic features by templating wings of butterflies \textit{Morpho menelaus}. Optics Communications 284, 2376 (2011).
- B. Dong, X. Liu, T. Zhan, L. Jiang, H. Yin, F. Liu, and J. Zi, Structural coloration and photonic pseudogap in natural random close-packing photonic structures. Optics Express 18, 14430 (2010).
- F. Liu, G. Wang, L. Jiang, and B. Dong, Structural colouration and optical effects in the wings of Papilio peranthus. J. Optics 12, 065301 (2010).
- J. Xue, B. Dong, X. Wang, R. Yang, Z. Xua, Y. Chen, E. Huq, W. Zeng, X. Qu, and R. Liu, Surface plasmon enhanced transmission through gold planar crystals with various aperture arrangements. Microelectron. Eng. 87, 1340 (2010).
- Z. Xu, B. Dong, J. Xue, R. Yang, B. Lu, S. Deng, Z. Li, W. Lu, Y. Chen, E. Huq, X. Qu, and R. Liu, Surface plasmon polariton coupling induced transmission of subwavelength metallic grating with waveguide layer. Microelectron. Eng. 87, 1297 (2010).
- S. Deng, B. Lu, B. Dong, J. Wan, Z. Shu, J. Xue, Y. Chen, E. Huq, R. Liu, and X. Qu, Effective polarization control of metallic planar chiral metamaterials with complementary rosette pattern fabricated by nanoimprint lithography. Microelectron. Eng. 87, 985 (2010).
- F. Liu, B. Dong, X. Liu, Y. Zheng, and J. Zi, Structural color change in longhorn beetles Tmesisternus isabellae. Optics Express 17, 16183 (2009).
- J. Xue, W. Zhou, B. Dong, X. Wang, Y. Chen, E. Huq, W. Zeng, X. Qu, and R. Liu, Surface plasmon enhanced transmission through planar gold quasicrystals fabricated by focused ion beam technique. Microelectron. Eng. 86, 1131 (2009).
- F. Liu, H. Yin, B. Dong, Y. Qing, L. Zhao, S. Meyer, X. Liu, J. Zi, and B. Chen, Inconspicuous structural coloration in the elytra of beetles \textit{Chlorophila obscuripennis} (Coleoptera). Phys. Rev. E 77, 012901 (2008). Highlighted in Nature China
- H. Yin, L. Shi, J. Sha, Y. Li, Y. Qin, B. Dong, S. Meyer, X. Liu, L. Zhao, and J. Zi, Iridescence in the neck feathers of domestic pigeons. Phys. Rev. E 74, 051916 (2006).
- J. Zi, B. Dong, T. R. Zhan, and X. H. Liu (2012). Photonic structures for coloration in the biological world. Bioinspiration: from nano to micro scales, X. Y. Liu (ed.), Springer.
- F. Liu, B. Dong, and X. H. Liu (2012). Bio-Inspired photonic structures: prototypes, fabrications and devices. Optical Devices in Communication and Computation, Peng Xi (ed.), InTech.