Selected Publications

  • Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography
  • H. Li*, B. Dong*, X. Zhang*, X. Shu, X. Chen, R. Hai, D. Czaplewski, H. F. Zhang, and C. Sun
  • Nature Communications 10, 4277 (2019)

    • A disposable ultrasound-sensing chronic cranial window (usCCW) featuring an integrated transparent nanophotonic ultrasonic detector fabricated using soft nanoimprint lithography process. We optimize the sensor design and the associated fabrication process to significantly improve detection sensitivity and reliability, which are critical for the intend longitudinal in vivo investigations. Surgically implanting the usCCW on the skull creates a self-contained environment, maintaining optical access while eliminating the need for external ultrasound coupling medium for photoacoustic imaging. Using this usCCW, we demonstrate photoacoustic microscopy of cortical vascular network in live mice over 28 days.

  • Optical detection of ultrasound in photoacoustic imaging
  • B. Dong, C. Sun, and H. F. Zhang
  • IEEE Transactions on Biomedical Engineering 64, 4 (2017)

    • A comprehensive review introduced recent technological advances in optical methods of ultrasound detection by classifying them based on their implementations in photoacoustic imaging. An overall comparison of all the optical ultrasound detection methods was discussed and a theoretical framework was further introduced to generalize sensitivity, bandwidth, and spatial responses of optical ultrasound detection geometries.

  • Super-resolution intrinsic fluorescence imaging utilizing native, unmodified nucleic acids for contrast
  • B. Dong*, L. Almassalha*, Y. Stypula-Cyrus, B. E. Urban, J. E. Chandler, T. Nguyen, C. Sun, H. F. Zhang, and V. Backman
  • Proc. Natl. Acad. Sci. USA 113, 9716 (2016).

    • The first demonstration of sub-diffraction-resolution imaging of cellular structures using intrinsic contrast from unmodified DNA. With a demonstrated sub-20-nm resolution, this technique provides an ideal way to visualize the spatial organization of single or groups of nucleosomes and to quantitatively estimate the nucleosome occupancy level of DNA in unstained chromosomes and nuclei. It offers a unique possibility to study the DNA epigenetic states using sub-diffractional analysis of the chromosomal organization.

  • Super-resolution spectroscopic microscopy via photon localization
  • B. Dong*, L. Almassalha*, B. E. Urban*, T. Nguyen*, S. Khuon, T.-L. Chew, V. Backman, C. Sun, and H. F. Zhang
  • Nature Communications 7, 12290 (2016)

    • A wide-field spectroscopic optical super-resolution imaging technology, called spectroscopic photon localization microscopy, is capable of simultaneously capturing the spatial distributions of photons emitted by individual molecules and their inherent spectroscopic signatures with sub-nm spectral resolution.

  • Gigahertz all-optical modulation using reconfigurable nanophotonic metamolecules
  • B. Dong*, X. Chen*, F. Zhou, C. Wang, H. F. Zhang, and C. Sun
  • Nano Letters 16, 7690 (2016)

    • A novel design of "metamolecule" that supports co-localized magnetic resonance at optical frequency and vibration resonance at GHz frequency with a deep-sub-diffraction-limit spatial confinement (~lambda2/100). The coherent coupling of those two distinct resonances manifests a strong optical force allowing the metamolecules to dynamically change their optical properties upon the incident light.

  • Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection
  • B. Dong, H. Li, Z. Zhang, K. Zhang, S. Chen, C. Sun, and H. F. Zhang
  • Optica 2, 169-176 (2015)

    • Development of a cover-slip type transparent optical ultrasonic sensor based on a polymeric micro-ring resonator to satisfy the high demands of ultrasonic sensing. Micro-ring resonator provides extremely high sensitivity, ultra-broad bandwidth, and wider angular sensitivity, offering a favorable solution for high-resolution photoacoustic microscopy. Its unique design further provides the ease of integrating photoacoustic microscopy with established microscopic modalities to achieve simultaneous multi-functional imaging.

  • Quantitative imaging of rapidly decaying evanescent fields using plasmonic near-field scanning optical microscopy
  • Z. Zhang*, P. Ahn*, B. Dong*, O. Balogun, and C. Sun
  • Scientific Reports 3, 2803 (2013)

    • A plasmonic near-field scanning optical microscopy (p-NSOM) technique that incorporates a nanofocusing probe for adiabatic focusing of propagating surface plasmon polaritons at the probe apex, and for enhanced coupling of evanescent waves to the far-field. In addition, a harmonic demodulation technique is employed to suppress the contribution of the background. The experimental results show strong evidence of background free near-field imaging using the new p-NSOM technique.

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